POM
Orodar tablets – 3’s
- Sulfadoxine: 500 mg per tablet
- Pyrimethamine: 25 mg per tablet
- Total Therapeutic Dose: 1500mg Sulfadoxine / 75mg Pyrimethamine
Sh 3,000
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Orodar is indicated for the following therapeutic and prophylactic applications:
- Uncomplicated Malaria Treatment: Used to cure acute, uncomplicated cases of P. falciparum malaria in areas where the parasite remains sensitive to Sulfadoxine/Pyrimethamine (SP).
- Intermittent Preventive Treatment in Pregnancy (IPTp): The definitive public health use. The drug is administered at scheduled antenatal visits under Directly Observed Treatment (DOT) to prevent malaria in the placenta, thereby reducing maternal anemia and infant low birth weight.
STANDARD ADULT DOSAGE: For Orodar (Sulfadoxine/Pyrimethamine), the required single therapeutic dose for both treatment and IPTp is THREE (3) TABLETS taken together.
Dosage and Administration
The entire dose must be taken at once, as a single administration:
- Standard Adult Dose (IPTp/Treatment): Three (3) tablets are taken simultaneously.
- Administration: Swallow the tablets whole with food or a glass of milk. Food intake is critical as it significantly improves drug absorption and minimizes gastrointestinal side effects.
- IPTp Schedule: Doses are typically administered at each scheduled Antenatal Care (ANC) visit, starting in the second trimester, with doses separated by at least one month.
Severe Warnings and Contraindications
Due to the sulfonamide component, Orodar requires careful medical supervision:
IMMEDIATE ATTENTION REQUIRED: If you develop a fever, sore throat, or a widespread, severe skin rash (with or without blisters), stop taking Orodar immediately and seek emergency medical care. These symptoms can signal life-threatening severe skin reactions (e.g., Stevens-Johnson Syndrome).
- Sulfa Allergy: Contradicted in patients with a history of hypersensitivity to sulfonamides or Pyrimethamine.
- G6PD Deficiency: Use is cautioned in individuals with Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, as it can trigger severe hemolytic anemia.
- Megaloblastic Anemia: Should not be used in patients with pre-existing megaloblastic anemia due to confirmed folate deficiency.
Side Effects and Interactions
Common Side Effects: Nausea, vomiting, headache, and mild skin reactions.
Drug Interactions: Concurrent use with other drugs that inhibit folic acid metabolism, such as Trimethoprim or Methotrexate, is dangerous as it significantly increases the risk of adverse blood disorders.
Orodar Summary Table (3-Tablet Dose)
| Detail | Information |
|---|---|
| Active Components | Sulfadoxine (500mg) / Pyrimethamine (25mg) |
| Standard Adult Dose | THREE (3) Tablets (Single Dose) |
| Primary Program Use | IPTp (Intermittent Preventive Treatment in Pregnancy) under DOT |
| Warning Focus | Severe Skin Reactions, Sulfa Allergy, G6PD Deficiency |
Haki zote zimehifadhiwa (All rights reserved). AfyaDepo 2025.
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Details
Orodar is indicated for the following therapeutic and prophylactic applications:
- Uncomplicated Malaria Treatment: Used to cure acute, uncomplicated cases of P. falciparum malaria in areas where the parasite remains sensitive to Sulfadoxine/Pyrimethamine (SP).
- Intermittent Preventive Treatment in Pregnancy (IPTp): The definitive public health use. The drug is administered at scheduled antenatal visits under Directly Observed Treatment (DOT) to prevent malaria in the placenta, thereby reducing maternal anemia and infant low birth weight.
STANDARD ADULT DOSAGE: For Orodar (Sulfadoxine/Pyrimethamine), the required single therapeutic dose for both treatment and IPTp is THREE (3) TABLETS taken together.
Dosage and Administration
The entire dose must be taken at once, as a single administration:
- Standard Adult Dose (IPTp/Treatment): Three (3) tablets are taken simultaneously.
- Administration: Swallow the tablets whole with food or a glass of milk. Food intake is critical as it significantly improves drug absorption and minimizes gastrointestinal side effects.
- IPTp Schedule: Doses are typically administered at each scheduled Antenatal Care (ANC) visit, starting in the second trimester, with doses separated by at least one month.
Severe Warnings and Contraindications
Due to the sulfonamide component, Orodar requires careful medical supervision:
IMMEDIATE ATTENTION REQUIRED: If you develop a fever, sore throat, or a widespread, severe skin rash (with or without blisters), stop taking Orodar immediately and seek emergency medical care. These symptoms can signal life-threatening severe skin reactions (e.g., Stevens-Johnson Syndrome).
- Sulfa Allergy: Contradicted in patients with a history of hypersensitivity to sulfonamides or Pyrimethamine.
- G6PD Deficiency: Use is cautioned in individuals with Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, as it can trigger severe hemolytic anemia.
- Megaloblastic Anemia: Should not be used in patients with pre-existing megaloblastic anemia due to confirmed folate deficiency.
Side Effects and Interactions
Common Side Effects: Nausea, vomiting, headache, and mild skin reactions.
Drug Interactions: Concurrent use with other drugs that inhibit folic acid metabolism, such as Trimethoprim or Methotrexate, is dangerous as it significantly increases the risk of adverse blood disorders.
Orodar Summary Table (3-Tablet Dose)
| Detail | Information |
|---|---|
| Active Components | Sulfadoxine (500mg) / Pyrimethamine (25mg) |
| Standard Adult Dose | THREE (3) Tablets (Single Dose) |
| Primary Program Use | IPTp (Intermittent Preventive Treatment in Pregnancy) under DOT |
| Warning Focus | Severe Skin Reactions, Sulfa Allergy, G6PD Deficiency |
Haki zote zimehifadhiwa (All rights reserved). AfyaDepo 2025.
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