CheckNOW HIV Self Test Kit

Details

The CheckNOW HIV Self Test Kit is an in-vitro diagnostic tool used for qualitative detection of antibodies to Human Immunodeficiency Virus Type 1 and Type 2 (HIV-1 and HIV-2). Its primary purpose is screening, allowing individuals to quickly determine their HIV status privately. For customers in Africa and Tanzania, where widespread testing is crucial for achieving global targets (e.g., UNAIDS 95-95-95), self-testing removes barriers related to stigma, distance, and time constraints associated with traditional clinic-based testing.

Available Product Formulations (Kit Contents)

The kit typically contains all necessary components for a single, complete test:

• Test Device: Cassette or strip containing chemical reagents (replaces “Active Ingredients”).
• Sample Collection Tool: Either an oral swab or a sterile safety lancet (for finger prick blood).
• Buffer/Developer Solution: Liquid solution required for the test reaction.
• Accessories: Instructions for Use, disposable items (e.g., plaster, alcohol swab).

Uses (Diagnostic Application)

The main use is to determine preliminary HIV status:

• Initial Screening: Providing a rapid, reliable preliminary result for individuals aged 18 and older.
• Repeat Testing: Encouraging periodic testing for individuals engaged in high-risk behaviors.
• Linkage to Care: Facilitating immediate connection to confirmatory testing and antiretroviral therapy (ART) services if the result is reactive (positive).

How to Use (Procedure/Dosing)

This replaces “Dosage.” The user must follow the instructions precisely, using the kit’s contents only once.

Side Effects (Post-Test Experience)

Since this is a diagnostic device, there are no pharmacological side effects. The primary physical discomfort is a brief, minimal pain at the finger prick site (if using the blood-based version). The most significant impact is emotional: users may experience anxiety, stress, or distress regarding the result. Users should ensure they have adequate emotional or counseling support available before and after testing.

Interactions (Operational Factors)

Warnings

Key safety and procedural warnings:

• Window Period: All HIV tests have a “window period” (the time between infection and when the antibodies can be detected). Testing too soon after a potential exposure (e.g., less than 3 months for oral fluid tests) may give a false-negative result.
• Non-Reactive Result: A non-reactive (negative) result is only definitive if the user has not had any potential exposure during the window period. Repeat testing is advised if exposure occurred recently.
• Sharps Disposal: Dispose of the lancet and all contaminated materials safely in a puncture-proof container (e.g., a plastic bottle) before discarding.

A Summary Table of Important Information

How CheckNOW HIV Self Test Kit Works (Mechanism of Action)

The CheckNOW test employs a chromatographic immunoassay principle. The device membrane contains highly specific synthetic peptides or recombinant proteins corresponding to the HIV-1 and HIV-2 antigens (typically gp41 and gp120/gp36). When the biological sample (oral fluid or blood) is mixed with the buffer solution, any HIV antibodies present in the sample migrate up the membrane by capillary action. These antibodies bind to the immobilized antigens in the test line (‘T’ line). A secondary reporter molecule, typically a colored particle (colloidal gold), subsequently binds to the captured human antibody, creating a visible line. A separate procedural control line (‘C’ line) confirms that the sample migrated correctly, ensuring the test is valid. The appearance of the ‘T’ line indicates a preliminary reactive result.