Details
Amirol 25 mg is a film-coated oral tablet containing
Amitriptyline Hydrochloride 25 mg. It belongs to the tricyclic antidepressant class and is used for mood disorders, chronic pain, headache prevention, and certain pediatric uses under specialist supervision.
Available Strengths / Forms
- 25 mg film-coated tablet (yellow, round)
Main Indications
- Treatment of major depressive disorder in adults
- Neuropathic pain (e.g. nerve pain)
- Preventive treatment for migraine and chronic tension-type headaches
- Nocturnal enuresis in children (6+ years) when other treatments failed and organic causes excluded
Dosage & Usage Instructions
- Start at a low dose, typically 25 mg once or twice daily, as decided by physician.
- Increase gradually in steps (e.g. 25 mg increments) if needed for effect and tolerability.
- Take with meals to reduce gastrointestinal upset.
- Do not stop abruptly; taper off under medical guidance.
Side Effects / Potential Risks
- Common: drowsiness, dry mouth, constipation, blurred vision, urinary retention
- Less common: orthostatic hypotension (drop in blood pressure when standing), weight gain, increase in heart rate
- Serious risks: risk of suicidal ideation especially in younger patients; cardiac conduction effects; overdose is serious.
Interactions / Compatibility
- Interacts with MAO inhibitors: contraindicated; requires washout period when switching.
- Caution with other CNS depressants (e.g. alcohol, sedatives) due to additive sedation effects.
- May interact with drugs that affect cardiac conduction.
Warnings & Precautions
- Not recommended for pediatric depression under 18 years.
- Use with caution in elderly, those with cardiovascular disease, glaucoma, urinary retention.
- Monitor for worsening mood or suicidal thoughts.
- Avoid overdose; ensure compliance and correct dosing.
- Store in a cool, dry place, protected from light.
Quick Facts Table
| Feature |
Details |
| Drug Class |
Tricyclic Antidepressant (TCA) |
| Active Ingredient |
Amitriptyline Hydrochloride 25 mg |
| Route |
Oral Tablet |
| Typical Onset |
2-4 weeks for depression; earlier for pain relief or headache prevention |
| Duration of Use |
Usually several months depending on indication and clinical response |
| Common Side Effects |
Drowsiness, dry mouth, constipation, urinary retention |
| Serious Warnings |
Suicidality risk, cardiac effects, avoid abrupt withdrawal |
Mechanism of Action
Amitriptyline works by inhibiting the reuptake of neurotransmitters serotonin and norepinephrine in the brain, increasing their levels in synaptic clefts. It also has secondary actions blocking certain receptors (e.g. histamine, alpha-adrenergic) which contribute to its sedative, pain modulation, and side-effect profile.
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