Details
Aminophylline Injection 25mg/mL is a fast-acting bronchodilator used in the treatment of acute asthma, chronic bronchitis, emphysema, and other obstructive airway diseases. It helps relax the smooth muscles of the airways, improving airflow and breathing.
Form/Strength
- 25mg/mL solution (usually in 10mL ampoule or vial)
- For intravenous use only (slow injection or infusion)
Main Uses
- Acute asthma attacks and severe bronchospasm
- Chronic obstructive pulmonary disease (COPD)
- Cardiac asthma and respiratory distress
Dosage & Administration
- Administer slow IV injection (over 10–20 minutes) or by IV infusion under close monitoring.
- Adult dose: 250mg (10mL) diluted and given slowly.
- Paediatric dose: Adjust according to weight and clinical response.
Side Effects
- Nausea, vomiting, headache
- Restlessness, palpitations
- Hypotension or arrhythmia (if injected too fast)
Contraindications
- Hypersensitivity to xanthine derivatives
- Peptic ulcer, severe heart disease, or epilepsy
Storage & Handling
- Store below 25°C, protect from light.
- Do not refrigerate or freeze.
Quick Facts Table
| Feature |
Details |
| Active Ingredient |
Aminophylline 25mg/mL |
| Route |
Intravenous (IV) |
| Action |
Bronchodilator (relaxes airway muscles) |
| Onset |
Within minutes |
| Common Uses |
Asthma, COPD, Bronchospasm |
| Supervision |
Use only under medical supervision |
Mechanism of Action
Aminophylline inhibits phosphodiesterase, leading to increased cyclic AMP levels in smooth muscle cells. This results in relaxation of bronchial muscles and improved airflow in the lungs.
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